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Aβ vaccination, but not nitro-NSAID treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid.

Vaccination with Aβ(1–42) and treatment with NCX-2216, a novel nitric oxide releasing flurbiprofen derivative, have each been shown separately to reduce amyloid deposition in transgenic mice and have been suggested as potential therapies for Alzheimer’s disease. In the current study we treated doubl...

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Hlavní autoři: Wilcock, Donna M., Jantzen, Paul T., Li, Qingyou, Morgan, Dave, Gordon, Marcia N.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857306/
https://ncbi.nlm.nih.gov/pubmed/17137722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2006.10.020
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