Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. As most Alzheimer disease cases occur well past midlife, the current study examined adoptive transfer of anti-Aβ antibodies...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wilcock, Donna M, Rojiani, Amyn, Rosenthal, Arnon, Subbarao, Sangeetha, Freeman, Melissa J, Gordon, Marcia N, Morgan, Dave
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC539292/
https://ncbi.nlm.nih.gov/pubmed/15588287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-1-24
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados