Loading...

Deglycosylated Anti-Aβ Antibody Dose–Response Effects on Pathology and Memory in APP Transgenic Mice

Anti-Aβ antibody administration to amyloid-depositing transgenic mice can reverse amyloid pathology and restore memory function. However, in old mice, these treatments also increase vascular leakage and promote formation of vascular amyloid deposits. Deglycosylated antibodies with reduced affinity f...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Neuroimmune Pharmacol
Main Authors: Karlnoski, Rachel A., Rosenthal, Arnon, Alamed, Jennifer, Ronan, Victoria, Gordon, Marcia N., Gottschall, Paul E., Grimm, Jan, Pons, Jaume, Morgan, Dave
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072283/
https://ncbi.nlm.nih.gov/pubmed/18607758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11481-008-9114-6
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!