Intracranial Injection of AAV Expressing NEP but Not IDE Reduces Amyloid Pathology in APP+PS1 Transgenic Mice

The accumulation of β-amyloid peptides in the brain has been recognized as an essential factor in Alzheimer’s disease pathology. Several proteases, including Neprilysin (NEP), endothelin converting enzyme (ECE), and insulin degrading enzyme (IDE), have been shown to cleave β-amyloid peptides (Aβ). W...

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Detalhes bibliográficos
Main Authors: Carty, Nikisha, Nash, Kevin R., Brownlow, Milene, Cruite, Dana, Wilcock, Donna, Selenica, Maj-Linda B., Lee, Daniel C., Gordon, Marcia N., Morgan, Dave
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610740/
https://ncbi.nlm.nih.gov/pubmed/23555730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059626
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