Intracranial Injection of AAV Expressing NEP but Not IDE Reduces Amyloid Pathology in APP+PS1 Transgenic Mice

The accumulation of β-amyloid peptides in the brain has been recognized as an essential factor in Alzheimer’s disease pathology. Several proteases, including Neprilysin (NEP), endothelin converting enzyme (ECE), and insulin degrading enzyme (IDE), have been shown to cleave β-amyloid peptides (Aβ). W...

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Autors principals: Carty, Nikisha, Nash, Kevin R., Brownlow, Milene, Cruite, Dana, Wilcock, Donna, Selenica, Maj-Linda B., Lee, Daniel C., Gordon, Marcia N., Morgan, Dave
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610740/
https://ncbi.nlm.nih.gov/pubmed/23555730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059626
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