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HUMAN 15-LOX-1 ACTIVE SITE MUTATIONS ALTER INHIBITOR BINDING AND DECREASE POTENCY

Human 15-Lipoxygenase-1 (h15-LOX-1 or h12/15-LOX) reacts with polyunsaturated fatty acids and produces bioactive lipid derivatives that are implicated in many important human diseases. One such disease is stroke, which is the fifth leading cause of death and the first leading cause of disability in...

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Dettagli Bibliografici
Pubblicato in:Bioorg Med Chem
Autori principali: Armstrong, Michelle, van Hoorebeke, Christopher, Horn, Thomas, Deschamps, Joshua, Freedman, J. Cody, Kalyanaraman, Chakrapani, Jacobson, Matthew P., Holman, Theodore
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065787/
https://ncbi.nlm.nih.gov/pubmed/27647374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.063
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