Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases

por Offenbacher, Adam R., Holman, Theodore R.
Publicado no Molecules (2020)

SUBSTRATE SPECIFICITY EFFECTS OF LIPOXYGENASE PRODUCTS AND INHIBITORS ON SOYBEAN LIPOXYGENASE-1

por Wecksler, Aaron T., Garcia, Natalie K., Holman, Theodore R.
Publicado em 2009

PSEUDOPEROXIDASE INVESTIGATIONS OF HYDROPEROXIDES AND INHIBITORS WITH HUMAN LIPOXYGENASES

por Hoobler, Eric K., Holz, Charles, Holman, Theodore R.
Publicado em 2013

A HIGH THROUGHPUT MASS SPECTROMETRIC ASSAY FOR DISCOVERY OF HUMAN LIPOXYGENASE INHIBITORS AND ALLOSTERIC EFFECTORS

por Jameson, J. Brian, Kenyon, Victor, Holman, Theodore R.
Publicado no Anal Biochem (2015)

The potential of 12/15-lipoxygenase inhibitors in stroke therapy

por van Leyen, Klaus, Holman, Theodore R, Maloney, David J
Publicado no Future Med Chem (2014)

Substrate Specificity Changes for Human Reticulocyte and Epithelial 15-Lipoxygenases Reveal Allosteric Product Regulation

por Wecksler, Aaron T., Kenyon, Victor, Deschamps, Joshua D., Holman, Theodore R.
Publicado em 2008

INHIBITORY AND MECHANISTIC INVESTIGATIONS OF OXO-LIPIDS WITH HUMAN LIPOXYGENASE ISOZYMES

por Armstrong, Michelle M., Diaz, Giovanni, Kenyon, Victor, Holman, Theodore R.
Publicado em 2014

Differential Contribution of Lipoxygenase Isozymes to Nigrostriatal Vulnerability

por Chou, Vivian P., Holman, Theodore R., Manning-Bog, Amy B.
Publicado no Neuroscience (2012)

Mechanistic Investigations of Human Reticulocyte 15- and Platelet 12-Lipoxygenases with Arachidonic Acid

por Wecksler, Aaron T., Jacquot, Cyril, van der Donk, Wilfred A., Holman, Theodore R.
Publicado em 2009

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

por Chou, Vivian P., Ko, Novie, Holman, Theodore R., Manning-Boğ, Amy B.
Publicado em 2014

Kinetic and Spectroscopic Studies of N694C Lipoxygenase: A Probe of the Substrate Activation Mechanism of a Non-Heme Ferric Enzyme

por Neidig, Michael L., Wecksler, Aaron T., Schenk, Gerhard, Holman, Theodore R., Solomon, Edward I.
Publicado em 2007

ATP Allosterically Activates the Human 5-Lipoxygenase Molecular Mechanism of Arachidonic Acid and 5(S)-Hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic Acid

por Smyrniotis, Christopher J., Barbour, Shannon R., Xia, Zexin, Hixon, Mark S., Holman, Theodore R.
Publicado em 2014

Structure Activity Relationship Studies of Flavonoids as Potent Inhibitors of Human Platelet 12-hLO, Reticulocyte 15-hLO-1 and Prostate Epithelial 15-hLO-2

por Vasquez-Martinez, Yesseny, Ohri, Rachana V., Kenyon, Victor, Holman, Theodore R., Sepúlveda-Boza, Silvia
Publicado em 2007

KINETIC AND STRUCTURAL INVESTIGATIONS INTO THE ALLOSTERIC AND PH EFFECT ON SUBSTRATE SPECIFICITY OF HUMAN EPITHELIAL 15-LIPOXYGENASE-2

por Joshi, Netra, Hoobler, Eric K., Perry, Steven, Diaz, Giovanni, Fox, Brian, Holman, Theodore R.
Publicado em 2013

Contributions of 12/15-Lipoxygenase to bleeding in the brain following ischemic stroke

por Zheng, Yi, Liu, Yu, Karatas, Hulya, Yigitkanli, Kazim, Holman, Theodore R., van Leyen, Klaus
Publicado no Adv Exp Med Biol (2019)

Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential

por Green, Abigail R., Barbour, Shannon, Horn, Thomas, Carlos, Jose, Raskatov, Jevgenij A., Holman, Theodore R.
Publicado no Biochemistry (2016)

Synthesis of 11-Thialinoleic Acid and 14-Thialinoleic Acid, Inhibitors of Soybean and Human Lipoxygenases

por Jacquot, Cyril, McGinley, Chris M., Plata, Erik, Holman, Theodore R., van der Donk, Wilfred A.
Publicado em 2008

Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation(1)

por Ikei, Kenneth N., Yeung, Jennifer, Apopa, Patrick L., Ceja, Jesús, Vesci, Joanne, Holman, Theodore R., Holinstat, Michael
Publicado em 2012

Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes

por Tersey, Sarah A., Bolanis, Esther, Holman, Theodore R., Maloney, David J., Nadler, Jerry L., Mirmira, Raghavendra G.
Publicado no Mol Endocrinol (2015)

5S,15S-Dihydroperoxyeicosatetraenoic acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Retic...

por Green, Abigail R., Freedman, Cody, Tena, Jennyfer, Tourdot, Benjamin E., Liu, Benjamin, Holinstat, Michael, Holman, Theodore R.
Publicado no Biochemistry (2018)