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Substrate Specificity Changes for Human Reticulocyte and Epithelial 15-Lipoxygenases Reveal Allosteric Product Regulation

Human reticulocyte 15-lipoxygenase (15-hLO-1) and epithelial 15-lipoxygenase (15-hLO-2) have been implicated in a number of human diseases, with differences in their substrate specificity potentially playing a central role. In the current paper, we present a novel method to accurately measure the su...

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Main Authors: Wecksler, Aaron T., Kenyon, Victor, Deschamps, Joshua D., Holman, Theodore R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2603187/
https://ncbi.nlm.nih.gov/pubmed/18570379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800550n
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