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Kinetic and Structural Investigations of the Allosteric Site in Human Epithelial 15-Lipoxygenase-2
Allosteric regulation of human lipoxygenase (hLO) activity has recently been implicated in the cellular biology of prostate cancer. In the current work, we present isotope effect, pH and substrate inhibitor data of epithelial 15-hLO-2, which probe the allosteric effects on its mechanistic behavior....
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746553/ https://ncbi.nlm.nih.gov/pubmed/19645454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9009242 |
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