Isotope Sensitive Branching and Kinetic Isotope Effects in the Reaction of Deuterated Arachidonic Acids with Human 12- and 15-Lipoxygenases

Lipoxygenases (LOs) catalyze lipid peroxidation and have been implicated in a number of human diseases connected to oxidative stress and inflammation. These enzymes have also attracted considerable attention due to large kinetic isotope effects (30−80) for the rate-limiting hydrogen abstraction step...

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Main Authors: Jacquot, Cyril, Wecksler, Aaron T., McGinley, Chris M., Segraves, Erika N., Holman, Theodore R., Donk, Wilfred A. van der
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574664/
https://ncbi.nlm.nih.gov/pubmed/18547056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800308q
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