HUMAN 15-LOX-1 ACTIVE SITE MUTATIONS ALTER INHIBITOR BINDING AND DECREASE POTENCY

Human 15-Lipoxygenase-1 (h15-LOX-1 or h12/15-LOX) reacts with polyunsaturated fatty acids and produces bioactive lipid derivatives that are implicated in many important human diseases. One such disease is stroke, which is the fifth leading cause of death and the first leading cause of disability in...

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Xehetasun bibliografikoak
Argitaratua izan da:Bioorg Med Chem
Egile Nagusiak: Armstrong, Michelle, van Hoorebeke, Christopher, Horn, Thomas, Deschamps, Joshua, Freedman, J. Cody, Kalyanaraman, Chakrapani, Jacobson, Matthew P., Holman, Theodore
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065787/
https://ncbi.nlm.nih.gov/pubmed/27647374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.063
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