HUMAN 15-LOX-1 ACTIVE SITE MUTATIONS ALTER INHIBITOR BINDING AND DECREASE POTENCY

Human 15-Lipoxygenase-1 (h15-LOX-1 or h12/15-LOX) reacts with polyunsaturated fatty acids and produces bioactive lipid derivatives that are implicated in many important human diseases. One such disease is stroke, which is the fifth leading cause of death and the first leading cause of disability in...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Armstrong, Michelle, van Hoorebeke, Christopher, Horn, Thomas, Deschamps, Joshua, Freedman, J. Cody, Kalyanaraman, Chakrapani, Jacobson, Matthew P., Holman, Theodore
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065787/
https://ncbi.nlm.nih.gov/pubmed/27647374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.063
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