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Proteasome regulates turnover of toxic human amylin in pancreatic cells
Toxic human amylin (hA) oligomers and aggregates are implicated in the pathogenesis of type 2 diabetes mellitus (T2DM). Although recent studies demonstrated a causal connection between hA uptake and toxicity in pancreatic cells, the mechanism of amylin’s clearance following its internalization and i...
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| Publicado no: | Biochem J |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5056598/ https://ncbi.nlm.nih.gov/pubmed/27340132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160026 |
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