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Apoptosis Signal Regulating Kinase-1 and NADPH Oxidase Mediate Human Amylin Evoked Redox Stress and Apoptosis in Pancreatic Beta-Cells

Misfolded toxic human islet amyloid polypeptide or amylin (hA) and plasma membrane-associated redox complex, NADPH oxidase (NOX), have been implicated in the islet β-cell demise associated with type-2 diabetes mellitus (T2DM). Studies show that hA accumulation is stressful to β-cells and that misfol...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta Biomembr
Main Authors: Singh, Sanghamitra, Bhowmick, Diti Chatterjee, Pany, Satyabrata, Joe, Myungkuk, Zaghlula, Noor, Jeremic, Aleksandar M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177334/
https://ncbi.nlm.nih.gov/pubmed/29627323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2018.03.024
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