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Apoptosis Signal Regulating Kinase-1 and NADPH Oxidase Mediate Human Amylin Evoked Redox Stress and Apoptosis in Pancreatic Beta-Cells
Misfolded toxic human islet amyloid polypeptide or amylin (hA) and plasma membrane-associated redox complex, NADPH oxidase (NOX), have been implicated in the islet β-cell demise associated with type-2 diabetes mellitus (T2DM). Studies show that hA accumulation is stressful to β-cells and that misfol...
Gorde:
| Argitaratua izan da: | Biochim Biophys Acta Biomembr |
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| Egile Nagusiak: | , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6177334/ https://ncbi.nlm.nih.gov/pubmed/29627323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2018.03.024 |
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