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Proteasome regulates turnover of toxic human amylin in pancreatic cells

Toxic human amylin (hA) oligomers and aggregates are implicated in the pathogenesis of type 2 diabetes mellitus (T2DM). Although recent studies demonstrated a causal connection between hA uptake and toxicity in pancreatic cells, the mechanism of amylin’s clearance following its internalization and i...

詳細記述

保存先:
書誌詳細
出版年:Biochem J
主要な著者: Singh, Sanghamitra, Trikha, Saurabh, Sarkar, Anjali, Jeremic, Aleksandar M.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056598/
https://ncbi.nlm.nih.gov/pubmed/27340132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160026
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