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Distinct Internalization Pathways of Human Amylin Monomers and Its Cytotoxic Oligomers in Pancreatic Cells

Toxic human amylin oligomers and aggregates are implicated in the pathogenesis of type 2 diabetes mellitus (TTDM). Although recent studies have shown that pancreatic cells can recycle amylin monomers and toxic oligomers, the exact uptake mechanism and trafficking routes of these molecular forms and...

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Detalhes bibliográficos
Main Authors: Trikha, Saurabh, Jeremic, Aleksandar M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760900/
https://ncbi.nlm.nih.gov/pubmed/24019897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073080
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