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Clustering and Internalization of Toxic Amylin Oligomers in Pancreatic Cells Require Plasma Membrane Cholesterol

Self-assembly of the human pancreatic hormone amylin into toxic oligomers and aggregates is linked to dysfunction of islet β-cells and pathogenesis of type 2 diabetes mellitus. Recent evidence suggests that cholesterol, an essential component of eukaryotic cells membranes, controls amylin aggregatio...

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Detalhes bibliográficos
Main Authors: Trikha, Saurabh, Jeremic, Aleksandar M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195610/
https://ncbi.nlm.nih.gov/pubmed/21865171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.240762
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