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Functional proteasome complex is required for turnover of islet amyloid polypeptide in pancreatic β-cells
Human islet amyloid polypeptide (hIAPP) is the principal constituent of amyloid deposits and toxic oligomers in the pancreatic islets. Together with hyperglycemia, hIAPP-derived oligomers and aggregates are important culprits in type 2 diabetes mellitus (T2DM). Here, we explored the role of the cell...
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| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6139561/ https://ncbi.nlm.nih.gov/pubmed/30012886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002414 |
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