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Human mitochondrial DNA replication machinery and disease
The human mitochondrial genome is replicated by DNA polymerase γ in concert with key components of the mitochondrial DNA (mtDNA) replication machinery. Defects in mtDNA replication or nucleotide metabolism cause deletions, point mutations, or depletion of mtDNA. The resulting loss of cellular respir...
Shranjeno v:
| izdano v: | Curr Opin Genet Dev |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5055853/ https://ncbi.nlm.nih.gov/pubmed/27065468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2016.03.005 |
| Oznake: |
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