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Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

As regulators of bioenergetics in the cell and the primary source of endogenous reactive oxygen species (ROS), dysfunctional mitochondria have been implicated for decades in the process of aging and age-related diseases. Mitochondrial DNA (mtDNA) is replicated and repaired by nuclear-encoded mtDNA p...

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Bibliografiske detaljer
Udgivet i:Ageing Res Rev
Main Authors: DeBalsi, Karen L., Hoff, Kirsten E., Copeland, William C.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086445/
https://ncbi.nlm.nih.gov/pubmed/27143693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.arr.2016.04.006
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