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Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

As regulators of bioenergetics in the cell and the primary source of endogenous reactive oxygen species (ROS), dysfunctional mitochondria have been implicated for decades in the process of aging and age-related diseases. Mitochondrial DNA (mtDNA) is replicated and repaired by nuclear-encoded mtDNA p...

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Detalhes bibliográficos
Publicado no:Ageing Res Rev
Main Authors: DeBalsi, Karen L., Hoff, Kirsten E., Copeland, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086445/
https://ncbi.nlm.nih.gov/pubmed/27143693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.arr.2016.04.006
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