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Defects in Mitochondrial DNA Replication and Human Disease
Mitochondrial DNA (mtDNA) is replicated by the DNA polymerase γ in concert with accessory proteins such as the mitochondrial DNA helicase, single stranded DNA binding protein, topoisomerase, and initiating factors. Nucleotide precursors for mtDNA replication arise from the mitochondrial salvage path...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3244805/ https://ncbi.nlm.nih.gov/pubmed/22176657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10409238.2011.632763 |
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