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Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutations
DNA polymerase γ (pol γ), encoded by POLG, is responsible for replicating human mitochondrial DNA. About 150 mutations in the human POLG have been identified in patients with mitochondrial diseases such as Alpers syndrome, progressive external ophthalmoplegia, and ataxia-neuropathy syndromes. Becaus...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3046768/ https://ncbi.nlm.nih.gov/pubmed/20927567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0530-4 |
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