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Human mitochondrial DNA replication machinery and disease

The human mitochondrial genome is replicated by DNA polymerase γ in concert with key components of the mitochondrial DNA (mtDNA) replication machinery. Defects in mtDNA replication or nucleotide metabolism cause deletions, point mutations, or depletion of mtDNA. The resulting loss of cellular respir...

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Dades bibliogràfiques
Publicat a:Curr Opin Genet Dev
Autors principals: Young, Matthew J., Copeland, William C.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055853/
https://ncbi.nlm.nih.gov/pubmed/27065468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2016.03.005
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