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Human mitochondrial DNA replication machinery and disease

The human mitochondrial genome is replicated by DNA polymerase γ in concert with key components of the mitochondrial DNA (mtDNA) replication machinery. Defects in mtDNA replication or nucleotide metabolism cause deletions, point mutations, or depletion of mtDNA. The resulting loss of cellular respir...

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Bibliographic Details
Published in:Curr Opin Genet Dev
Main Authors: Young, Matthew J., Copeland, William C.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5055853/
https://ncbi.nlm.nih.gov/pubmed/27065468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2016.03.005
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