Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication

Prions are the infectious agents causing transmissible spongiform encephalopathies (TSE), progressive, inexorably lethal neurological diseases. Antibodies targeting the globular domain (GD) of the cellular prion protein PrP(C) trigger a neurotoxic syndrome morphologically and molecularly similar to...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Frontzek, Karl, Pfammatter, Manuela, Sorce, Silvia, Senatore, Assunta, Schwarz, Petra, Moos, Rita, Frauenknecht, Katrin, Hornemann, Simone, Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042507/
https://ncbi.nlm.nih.gov/pubmed/27684562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163601
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