Prion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes

The accumulation of the scrapie prion protein PrP(Sc), a misfolded conformer of the cellular prion protein PrP(C), is a crucial feature of prion diseases. In the central nervous system, this process is accompanied by conspicuous microglia activation. The NLRP3 inflammasome is a multi-molecular compl...

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Udgivet i:PLoS One
Main Authors: Nuvolone, Mario, Sorce, Silvia, Schwarz, Petra, Aguzzi, Adriano
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324825/
https://ncbi.nlm.nih.gov/pubmed/25671600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117208
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