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Prion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes
The accumulation of the scrapie prion protein PrP(Sc), a misfolded conformer of the cellular prion protein PrP(C), is a crucial feature of prion diseases. In the central nervous system, this process is accompanied by conspicuous microglia activation. The NLRP3 inflammasome is a multi-molecular compl...
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| Izdano u: | PLoS One |
|---|---|
| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4324825/ https://ncbi.nlm.nih.gov/pubmed/25671600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117208 |
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