The Role of the NADPH Oxidase NOX2 in Prion Pathogenesis

Prion infections cause neurodegeneration, which often goes along with oxidative stress. However, the cellular source of reactive oxygen species (ROS) and their pathogenetic significance are unclear. Here we analyzed the contribution of NOX2, a prominent NADPH oxidase, to prion diseases. We found tha...

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Bibliografski detalji
Izdano u:PLoS Pathog
Glavni autori: Sorce, Silvia, Nuvolone, Mario, Keller, Annika, Falsig, Jeppe, Varol, Ahmet, Schwarz, Petra, Bieri, Monika, Budka, Herbert, Aguzzi, Adriano
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263757/
https://ncbi.nlm.nih.gov/pubmed/25502554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004531
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