The Role of the NADPH Oxidase NOX2 in Prion Pathogenesis

Prion infections cause neurodegeneration, which often goes along with oxidative stress. However, the cellular source of reactive oxygen species (ROS) and their pathogenetic significance are unclear. Here we analyzed the contribution of NOX2, a prominent NADPH oxidase, to prion diseases. We found tha...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Sorce, Silvia, Nuvolone, Mario, Keller, Annika, Falsig, Jeppe, Varol, Ahmet, Schwarz, Petra, Bieri, Monika, Budka, Herbert, Aguzzi, Adriano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263757/
https://ncbi.nlm.nih.gov/pubmed/25502554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004531
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