Genome-wide transcriptomics identifies an early preclinical signature of prion infection

The clinical course of prion diseases is accurately predictable despite long latency periods, suggesting that prion pathogenesis is driven by precisely timed molecular events. We constructed a searchable genome-wide atlas of mRNA abundance and splicing alterations during the course of disease in pri...

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Detalles Bibliográficos
Publicado en:PLoS Pathog
Main Authors: Sorce, Silvia, Nuvolone, Mario, Russo, Giancarlo, Chincisan, Andra, Heinzer, Daniel, Avar, Merve, Pfammatter, Manuela, Schwarz, Petra, Delic, Mirzet, Müller, Micha, Hornemann, Simone, Sanoudou, Despina, Scheckel, Claudia, Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360066/
https://ncbi.nlm.nih.gov/pubmed/32598380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008653
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