Genome-wide transcriptomics identifies an early preclinical signature of prion infection

The clinical course of prion diseases is accurately predictable despite long latency periods, suggesting that prion pathogenesis is driven by precisely timed molecular events. We constructed a searchable genome-wide atlas of mRNA abundance and splicing alterations during the course of disease in pri...

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Vydáno v:PLoS Pathog
Hlavní autoři: Sorce, Silvia, Nuvolone, Mario, Russo, Giancarlo, Chincisan, Andra, Heinzer, Daniel, Avar, Merve, Pfammatter, Manuela, Schwarz, Petra, Delic, Mirzet, Müller, Micha, Hornemann, Simone, Sanoudou, Despina, Scheckel, Claudia, Aguzzi, Adriano
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7360066/
https://ncbi.nlm.nih.gov/pubmed/32598380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008653
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