Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier

Transmissible spongiform encephalopathies (TSEs) are caused by the prion, which consists essentially of PrP(Sc), an aggregated, conformationally modified form of the cellular prion protein (PrP(C)). Although TSEs can be experimentally transmitted by intracerebral inoculation, most instances of infec...

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Publicado en:PLoS Pathog
Main Authors: Keller, Annika, Nuvolone, Mario, Abakumova, Irina, Chincisan, Andra, Reimann, Regina, Avar, Merve, Heinzer, Daniel, Hornemann, Simone, Wagner, Josephin, Kirschenbaum, Daniel, Voigt, Fabian F., Zhu, Caihong, Regli, Luca, Helmchen, Fritjof, Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264140/
https://ncbi.nlm.nih.gov/pubmed/30496289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007424
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