Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell line

Transmission of prion infectivity to susceptible murine cell lines has simplified prion titration assays and has greatly reduced the need for animal experimentation. However, murine cell models suffer from technical and biological constraints. Human cell lines might be more useful, but they are much...

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Bibliographic Details
Published in:Life Sci Alliance
Main Authors: Avar, Merve, Heinzer, Daniel, Steinke, Nicolas, Doğançay, Berre, Moos, Rita, Lugan, Severine, Cosenza, Claudia, Hornemann, Simone, Andréoletti, Olivier, Aguzzi, Adriano
Format: Artigo
Language:Inglês
Published: Life Science Alliance LLC 2020
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7335386/
https://ncbi.nlm.nih.gov/pubmed/32606072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000814
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