Protective anti‐prion antibodies in human immunoglobulin repertoires

Prion immunotherapy may hold great potential, but antibodies against certain PrP epitopes can be neurotoxic. Here, we identified > 6,000 PrP‐binding antibodies in a synthetic human Fab phage display library, 49 of which we characterized in detail. Antibodies directed against the flexible tail of...

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Foilsithe in:EMBO Mol Med
Main Authors: Senatore, Assunta, Frontzek, Karl, Emmenegger, Marc, Chincisan, Andra, Losa, Marco, Reimann, Regina, Horny, Geraldine, Guo, Jingjing, Fels, Sylvie, Sorce, Silvia, Zhu, Caihong, George, Nathalie, Ewert, Stefan, Pietzonka, Thomas, Hornemann, Simone, Aguzzi, Adriano
Formáid: Artigo
Teanga:Inglês
Foilsithe: John Wiley and Sons Inc. 2020
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7506995/
https://ncbi.nlm.nih.gov/pubmed/32776637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012739
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