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The biological function of the cellular prion protein: an update

The misfolding of the cellular prion protein (PrP(C)) causes fatal neurodegenerative diseases. Yet PrP(C) is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary elimination. Ablation of PrP(C) in mice results in well-defined structural and function...

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Détails bibliographiques
Publié dans:BMC Biol
Auteurs principaux: Wulf, Marie-Angela, Senatore, Assunta, Aguzzi, Adriano
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412054/
https://ncbi.nlm.nih.gov/pubmed/28464931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-017-0375-5
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