Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication

Prions are the infectious agents causing transmissible spongiform encephalopathies (TSE), progressive, inexorably lethal neurological diseases. Antibodies targeting the globular domain (GD) of the cellular prion protein PrP(C) trigger a neurotoxic syndrome morphologically and molecularly similar to...

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Publicat a:PLoS One
Autors principals: Frontzek, Karl, Pfammatter, Manuela, Sorce, Silvia, Senatore, Assunta, Schwarz, Petra, Moos, Rita, Frauenknecht, Katrin, Hornemann, Simone, Aguzzi, Adriano
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042507/
https://ncbi.nlm.nih.gov/pubmed/27684562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163601
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