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Computationally driven antibody engineering enables simultaneous humanization and thermostabilization
Humanization reduces the immunogenicity risk of therapeutic antibodies of non-human origin. Thermostabilization can be critical for clinical development and application of therapeutic antibodies. Here, we show that the computational antibody redesign method Computationally Driven Antibody Humanizati...
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| Foilsithe in: | Protein Eng Des Sel |
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| Main Authors: | , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Oxford University Press
2016
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5036863/ https://ncbi.nlm.nih.gov/pubmed/27334453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzw024 |
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