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Computationally driven antibody engineering enables simultaneous humanization and thermostabilization
Humanization reduces the immunogenicity risk of therapeutic antibodies of non-human origin. Thermostabilization can be critical for clinical development and application of therapeutic antibodies. Here, we show that the computational antibody redesign method Computationally Driven Antibody Humanizati...
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| Vydáno v: | Protein Eng Des Sel |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5036863/ https://ncbi.nlm.nih.gov/pubmed/27334453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzw024 |
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