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EpiSweep: Computationally-driven Reengineering of Therapeutic Proteins to Reduce immunogenicity while Maintaining Function

Therapeutic proteins are yielding ever more advanced and efficacious new drugs, but the biological origins of these highly effective therapeutics renders them subject to immune surveillance within the patient’s body. When recognized by the immune system as a foreign agent, protein drugs elicit a coo...

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Detalhes bibliográficos
Publicado no:Methods Mol Biol
Main Authors: Choi, Yoonjoo, Verma, Deeptak, Griswold, Karl E., Bailey-Kellogg, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142831/
https://ncbi.nlm.nih.gov/pubmed/27914063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-6637-0_20
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