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Computationally driven deletion of broadly distributed T cell epitopes in a biotherapeutic candidate
Biotherapeutics are subject to immune surveillance within the body, and anti-biotherapeutic immune responses can compromise drug efficacy and patient safety. Initial development of targeted antidrug immune memory is coordinated by T cell recognition of immunogenic subsequences, termed “T cell epitop...
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| Udgivet i: | Cell Mol Life Sci |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer Basel
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4234684/ https://ncbi.nlm.nih.gov/pubmed/24880662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-014-1652-x |
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