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Structure-based redesign of proteins for minimal T-cell epitope content
The protein universe displays a wealth of therapeutically relevant activities, but T cell driven immune responses to non-“self” biological agents present a major impediment to harnessing the full diversity of these molecular functions. Mutagenic T cell epitope deletion seeks to mitigate the immune r...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3763725/ https://ncbi.nlm.nih.gov/pubmed/23299435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.23213 |
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