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Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads

Anti-drug immune responses are a unique risk factor for biotherapeutics, and undesired immunogenicity can alter pharmacokinetics, compromise drug efficacy, and in some cases even threaten patient safety. To fully capitalize on the promise of biotherapeutics, more efficient and generally applicable p...

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Detalhes bibliográficos
Publicado no:Biotechnol Bioeng
Main Authors: Salvat, Regina S., Choi, Yoonjoo, Bishop, Alexandra, Bailey-Kellogg, Chris, Griswold, Karl E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452428/
https://ncbi.nlm.nih.gov/pubmed/25655032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.25554
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