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Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads
Anti-drug immune responses are a unique risk factor for biotherapeutics, and undesired immunogenicity can alter pharmacokinetics, compromise drug efficacy, and in some cases even threaten patient safety. To fully capitalize on the promise of biotherapeutics, more efficient and generally applicable p...
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| Veröffentlicht in: | Biotechnol Bioeng |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4452428/ https://ncbi.nlm.nih.gov/pubmed/25655032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.25554 |
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