Computer-guided binding mode identification and affinity improvement of an LRR protein binder without structure determination

Precise binding mode identification and subsequent affinity improvement without structure determination remain a challenge in the development of therapeutic proteins. However, relevant experimental techniques are generally quite costly, and purely computational methods have been unreliable. Here, we...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:PLoS Comput Biol
Huvudupphovsmän: Choi, Yoonjoo, Jeong, Sukyo, Choi, Jung-Min, Ndong, Christian, Griswold, Karl E., Bailey-Kellogg, Chris, Kim, Hak-Sung
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485979/
https://ncbi.nlm.nih.gov/pubmed/32866140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008150
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk