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Computer-guided binding mode identification and affinity improvement of an LRR protein binder without structure determination
Precise binding mode identification and subsequent affinity improvement without structure determination remain a challenge in the development of therapeutic proteins. However, relevant experimental techniques are generally quite costly, and purely computational methods have been unreliable. Here, we...
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| Publicat a: | PLoS Comput Biol |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7485979/ https://ncbi.nlm.nih.gov/pubmed/32866140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008150 |
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