Computer-based Engineering of Thermostabilized Antibody Fragments

We used the molecular modeling program Rosetta to identify clusters of amino acid substitutions in antibody fragments (scFvs and scAbs) that improve global protein stability and resistance to thermal deactivation. Using this methodology, we increased the melting temperature (T(m)) and resistance to...

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Detalhes bibliográficos
Publicado no:AIChE J
Main Authors: Lee, Jiwon, Der, Bryan S., Karamitros, Christos S., Li, Wenzong, Marshall, Nicholas M., Lungu, Oana I., Miklos, Aleksandr E., Xu, Jianqing, Kang, Tae Hyun, Lee, Chang-Han, Tan, Bing, Hughes, Randall A., Jung, Sang Taek, Ippolito, Gregory C., Gray, Jeffrey J., Zhang, Yan, Kuhlman, Brian, Georgiou, George, Ellington, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7181397/
https://ncbi.nlm.nih.gov/pubmed/32336757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/aic.16864
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