Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies

Mutation of surface residues to charged amino acids increases resistance to aggregation and can enable reversible unfolding. We have developed a protocol using the Rosetta computational design package that “supercharges” proteins while considering the energetic implications of each mutation. Using a...

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Gepubliceerd in:Chem Biol
Hoofdauteurs: Miklos, Aleksandr E., Kluwe, Christien, Der, Bryan S., Pai, Supriya, Sircar, Aroop, Hughes, Randall A., Berrondo, Monica, Xu, Jianqing, Codrea, Vlad, Buckley, Patricia E., Calm, Alena M., Welsh, Heather S., Warner, Candice R., Zacharko, Melody A., Carney, James P., Gray, Jeffrey J., Georgiou, George, Kuhlman, Brian, Ellington, Andrew D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583727/
https://ncbi.nlm.nih.gov/pubmed/22520751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.01.018
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