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Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies
Mutation of surface residues to charged amino acids increases resistance to aggregation and can enable reversible unfolding. We have developed a protocol using the Rosetta computational design package that “supercharges” proteins while considering the energetic implications of each mutation. Using a...
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| Izdano u: | Chem Biol |
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| Glavni autori: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5583727/ https://ncbi.nlm.nih.gov/pubmed/22520751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.01.018 |
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