Alternative Computational Protocols for Supercharging Protein Surfaces for Reversible Unfolding and Retention of Stability

Reengineering protein surfaces to exhibit high net charge, referred to as “supercharging”, can improve reversibility of unfolding by preventing aggregation of partially unfolded states. Incorporation of charged side chains should be optimized while considering structural and energetic consequences,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Der, Bryan S., Kluwe, Christien, Miklos, Aleksandr E., Jacak, Ron, Lyskov, Sergey, Gray, Jeffrey J., Georgiou, George, Ellington, Andrew D., Kuhlman, Brian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2013
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669367/
https://ncbi.nlm.nih.gov/pubmed/23741319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064363
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