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Structure-based non-canonical amino acid design to covalently crosslink an antibody–antigen complex
Engineering antibodies to utilize non-canonical amino acids (NCAA) should greatly expand the utility of an already important biological reagent. In particular, introducing crosslinking reagents into antibody complementarity determining regions (CDRs) should provide a means to covalently crosslink re...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4086636/ https://ncbi.nlm.nih.gov/pubmed/23680795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2013.05.003 |
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