Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

α-synuclein (α-syn) is a 140-residue intrinsically disordered protein that is involved in neuronal and synaptic vesicle plasticity but its aggregation to form amyloid fibrils is the hallmark of Parkinson’s disease (PD). The interaction between α-syn and lipid surfaces is believed to be a key feature...

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Bibliographic Details
Published in:Nat Chem Biol
Main Authors: Galvagnion, Céline, Buell, Alexander K., Meisl, Georg, Michaels, Thomas C.T., Vendruscolo, Michele, Knowles, Tuomas P.J., Dobson, Christopher M.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5019199/
https://ncbi.nlm.nih.gov/pubmed/25643172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1750
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