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Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
α-synuclein (α-syn) is a 140-residue intrinsically disordered protein that is involved in neuronal and synaptic vesicle plasticity but its aggregation to form amyloid fibrils is the hallmark of Parkinson’s disease (PD). The interaction between α-syn and lipid surfaces is believed to be a key feature...
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| Pubblicato in: | Nat Chem Biol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5019199/ https://ncbi.nlm.nih.gov/pubmed/25643172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1750 |
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