Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engineered priming immunogen are relatively common among humans. This priming immunogen has demonstrated the...

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Vydáno v:Cell
Hlavní autoři: Briney, Bryan, Sok, Devin, Jardine, Joseph G., Kulp, Daniel W., Skog, Patrick, Menis, Sergey, Jacak, Ronald, Kalyuzhniy, Oleksandr, de Val, Natalia, Sesterhenn, Fabian, Le, Khoa M., Ramos, Alejandra, Jones, Meaghan, Saye-Francisco, Karen L., Blane, Tanya R., Spencer, Skye, Georgeson, Erik, Hu, Xiaozhen, Ozorowski, Gabriel, Adachi, Yumiko, Kubitz, Michael, Sarkar, Anita, Wilson, Ian A., Ward, Andrew B., Nemazee, David, Burton, Dennis R., Schief, William R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018249/
https://ncbi.nlm.nih.gov/pubmed/27610570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.005
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