Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design

An optimal HIV vaccine should induce broadly neutralizing antibodies (bnAbs) that neutralize diverse viral strains and subtypes. However, potent bnAbs develop in only a small fraction of HIV-infected individuals, all contain rare features such as extensive mutation, insertions, deletions, and/or lon...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:PLoS Pathog
المؤلفون الرئيسيون: Jardine, Joseph G., Sok, Devin, Julien, Jean-Philippe, Briney, Bryan, Sarkar, Anita, Liang, Chi-Hui, Scherer, Erin A., Henry Dunand, Carole J., Adachi, Yumiko, Diwanji, Devan, Hsueh, Jessica, Jones, Meaghan, Kalyuzhniy, Oleksandr, Kubitz, Michael, Spencer, Skye, Pauthner, Matthias, Saye-Francisco, Karen L., Sesterhenn, Fabian, Wilson, Patrick C., Galloway, Denise M., Stanfield, Robyn L., Wilson, Ian A., Burton, Dennis R., Schief, William R.
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2016
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999182/
https://ncbi.nlm.nih.gov/pubmed/27560183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005815
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