Beta‐amyloid 1‐42 monomers, but not oligomers, produce PHF‐like conformation of Tau protein

The mechanistic relationship between amyloid β1‐42 (Aβ1‐42) and the alteration of Tau protein are debated. We investigated the effect of Aβ1‐42 monomers and oligomers on Tau, using mice expressing wild‐type human Tau that do not spontaneously develop Tau pathology. After intraventricular injection o...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Manassero, Giusi, Guglielmotto, Michela, Zamfir, Raluca, Borghi, Roberta, Colombo, Laura, Salmona, Mario, Perry, George, Odetti, Patrizio, Arancio, Ottavio, Tamagno, Elena, Tabaton, Massimo
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013016/
https://ncbi.nlm.nih.gov/pubmed/27406053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12500
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