Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis

The role of autophagy and its relationship with apoptosis in Alzheimer disease (AD) pathogenesis is poorly understood. Disruption of autophagy leads to buildup of incompletely digested substrates, amyloid-β (Aβ) peptide accumulation in vacuoles and cell death. Aβ, in turn, has been found to affect a...

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Detalhes bibliográficos
Main Authors: Guglielmotto, Michela, Monteleone, Debora, Piras, Antonio, Valsecchi, Valeria, Tropiano, Marta, Ariano, Stefania, Fornaro, Michele, Vercelli, Alessandro, Puyal, Julien, Arancio, Ottavio, Tabaton, Massimo, Tamagno, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Translational Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198366/
https://ncbi.nlm.nih.gov/pubmed/25136804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.30001
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